منابع مشابه
Oncogenes in Human Thyroid Cancers
Human thyroid epithelial (follicular) cells give rise to two malignant tumors—"follicular" carcinomas, which metastasize almost exclusively via the bloodstream, and "papillary" carcinomas, which metastasize predominantly via lymphatics (Williams, E. D. In: W. Duncan (ed.), Recent Results in Cancer Research: Thyroid Cancer, pp. 47-55. Berlin: Springer-Verlag, 1980). We have investigated whethe...
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Most retroviruses are innocuous to the cells they infect and do not encode transforming genes, yet many are implicated in naturally occurring cancers that arise at high frequency in virus-infected animals. It is now clear that the oncogenic properties of these viruses can be attributed to the stochastic activation of cellular oncogenes by the insertion of proviral DNA. Specific cancers ensue fr...
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High-molecular-weight DNA isolated from eight fresh human skin cancers occurring on sun-exposed body sites were assayed for their ability to transform NIH 3T3 cells. A cotransfection protocol using pSV2-neo DNA, which confers resistance to the antibiotic G418, was used to select cells that had taken up the transfected DNA. About 2 weeks after transfection, G418-resistant colonies were pooled an...
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ژورنال
عنوان ژورنال: European Journal of Cancer Supplements
سال: 2006
ISSN: 1359-6349
DOI: 10.1016/j.ejcsup.2006.04.037